Package: MultiSEp
Type: Package
Title: Predict Synthetic Lethality and Other Gene Dependency
        Relationships from Multiomics Data
Version: 4.1.3
BuildVignettes: TRUE
Authors@R: c(
    person("Adeline", "McKie", role = "aut"),
    person("Mark", "Wappett", role = "aut"),
    person("Ian", "Overton", email = "i.overton@qub.ac.uk", role = c("aut", "cre")))
Description: Predicts gene dependency relationships (GDRs) from
        functional genomics data. Regularised Gaussian mixture
        modelling may be applied for unsupervised clustering in
        addition to other data partitioning strategies. GDR analysis
        tools include discovery of synthetic lethal relationships and
        predicting population coverage for candidate drug targets from
        cancer patient mutational profiles. Functionality for
        visualisation is also available. 'MultiSEp' is applicable to
        data from a variety of sources including clinical cohorts,
        organoids and cell lines.
License: LGPL-2.1
Depends: R (>= 3.5.0)
Imports: pracma, pbapply, pbmcapply, reshape2, ggplot2, gtools,
        testthat, igraph, grid, patchwork, scales
Encoding: UTF-8
LazyData: true
LazyDataCompression: bzip2
NeedsCompilation: no
VignetteBuilder: knitr, rmarkdown
Suggests: rmarkdown, kableExtra, magrittr, knitr, dplyr
Language: en-GB
Packaged: 2026-09-26 09:52:53 UTC; root
Author: Adeline McKie [aut], Mark Wappett [aut], Ian Overton [aut, cre]
Maintainer: Ian Overton <i.overton@qub.ac.uk>
Config/pak/sysreqs: cmake libglpk-dev make libicu-dev libuv1-dev
        libxml2-dev
Repository: https://ianoverton.r-universe.dev
Date/Publication: 2026-08-27 10:30:02 UTC
RemoteUrl: https://github.com/cran/MultiSEp
RemoteRef: HEAD
RemoteSha: 704d059e704b80de65a6c6d1125c2e48a0c284e9